SrasV1, Main, Exploration, bibRecord, 001834

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.

Identifieur interne : 001834 ( Main/Exploration ); précédent : 001833; suivant : 001835

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.

Auteurs : Zhilin Ren [République populaire de Chine] ; Liming Yan ; Ning Zhang ; Yu Guo ; Cheng Yang ; Zhiyong Lou ; Zihe Rao

Source :

Protein & cell [ 1674-8018 ] ; 2013.

RBID : pubmed:23549610

Descripteurs français

KwdFr :
- Cysteine endopeptidases (métabolisme), Humains, Inhibiteurs de protéases (), Inhibiteurs de protéases (métabolisme), Inhibiteurs de protéases (pharmacologie), Isoxazoles (), Isoxazoles (pharmacologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), Pyrrolidones (), Pyrrolidones (pharmacologie), Rhinovirus (), Sites de fixation, Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (enzymologie).
MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Inhibiteurs de protéases, Protéines virales.
- pharmacologie : Inhibiteurs de protéases, Isoxazoles, Pyrrolidones.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Inhibiteurs de protéases, Isoxazoles, Pyrrolidones, Rhinovirus, Sites de fixation, Structure tertiaire des protéines, Virus du SRAS.

English descriptors

KwdEn :
- Binding Sites, Cysteine Endopeptidases (metabolism), Humans, Isoxazoles (chemistry), Isoxazoles (pharmacology), Protease Inhibitors (chemistry), Protease Inhibitors (metabolism), Protease Inhibitors (pharmacology), Protein Structure, Tertiary, Pyrrolidinones (chemistry), Pyrrolidinones (pharmacology), Rhinovirus (drug effects), SARS Virus (drug effects), SARS Virus (enzymology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemistry : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- chemical , metabolism : Cysteine Endopeptidases, Protease Inhibitors, Viral Proteins.
- chemical , pharmacology : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- drug effects : Rhinovirus, SARS Virus.
- enzymology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Binding Sites, Humans, Protein Structure, Tertiary.

DOI: 10.1007/s13238-013-2841-3
PubMed: 23549610

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.</title>
<author><name sortKey="Ren, Zhilin" sort="Ren, Zhilin" uniqKey="Ren Z" first="Zhilin" last="Ren">Zhilin Ren</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Liming" sort="Yan, Liming" uniqKey="Yan L" first="Liming" last="Yan">Liming Yan</name>
</author>
<author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
</author>
<author><name sortKey="Guo, Yu" sort="Guo, Yu" uniqKey="Guo Y" first="Yu" last="Guo">Yu Guo</name>
</author>
<author><name sortKey="Yang, Cheng" sort="Yang, Cheng" uniqKey="Yang C" first="Cheng" last="Yang">Cheng Yang</name>
</author>
<author><name sortKey="Lou, Zhiyong" sort="Lou, Zhiyong" uniqKey="Lou Z" first="Zhiyong" last="Lou">Zhiyong Lou</name>
</author>
<author><name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23549610</idno>
<idno type="pmid">23549610</idno>
<idno type="doi">10.1007/s13238-013-2841-3</idno>
<idno type="wicri:Area/PubMed/Corpus">001229</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001229</idno>
<idno type="wicri:Area/PubMed/Curation">001229</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001229</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001082</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001082</idno>
<idno type="wicri:Area/Ncbi/Merge">002643</idno>
<idno type="wicri:Area/Ncbi/Curation">002643</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002643</idno>
<idno type="wicri:Area/Main/Merge">001840</idno>
<idno type="wicri:Area/Main/Curation">001834</idno>
<idno type="wicri:Area/Main/Exploration">001834</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.</title>
<author><name sortKey="Ren, Zhilin" sort="Ren, Zhilin" uniqKey="Ren Z" first="Zhilin" last="Ren">Zhilin Ren</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Liming" sort="Yan, Liming" uniqKey="Yan L" first="Liming" last="Yan">Liming Yan</name>
</author>
<author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
</author>
<author><name sortKey="Guo, Yu" sort="Guo, Yu" uniqKey="Guo Y" first="Yu" last="Guo">Yu Guo</name>
</author>
<author><name sortKey="Yang, Cheng" sort="Yang, Cheng" uniqKey="Yang C" first="Cheng" last="Yang">Cheng Yang</name>
</author>
<author><name sortKey="Lou, Zhiyong" sort="Lou, Zhiyong" uniqKey="Lou Z" first="Zhiyong" last="Lou">Zhiyong Lou</name>
</author>
<author><name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name>
</author>
</analytic>
<series><title level="j">Protein & cell</title>
<idno type="eISSN">1674-8018</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding Sites</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Humans</term>
<term>Isoxazoles (chemistry)</term>
<term>Isoxazoles (pharmacology)</term>
<term>Protease Inhibitors (chemistry)</term>
<term>Protease Inhibitors (metabolism)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>Protein Structure, Tertiary</term>
<term>Pyrrolidinones (chemistry)</term>
<term>Pyrrolidinones (pharmacology)</term>
<term>Rhinovirus (drug effects)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cysteine endopeptidases (métabolisme)</term>
<term>Humains</term>
<term>Inhibiteurs de protéases ()</term>
<term>Inhibiteurs de protéases (métabolisme)</term>
<term>Inhibiteurs de protéases (pharmacologie)</term>
<term>Isoxazoles ()</term>
<term>Isoxazoles (pharmacologie)</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Protéines virales (métabolisme)</term>
<term>Pyrrolidones ()</term>
<term>Pyrrolidones (pharmacologie)</term>
<term>Rhinovirus ()</term>
<term>Sites de fixation</term>
<term>Structure tertiaire des protéines</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (enzymologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Isoxazoles</term>
<term>Protease Inhibitors</term>
<term>Pyrrolidinones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Protease Inhibitors</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Isoxazoles</term>
<term>Protease Inhibitors</term>
<term>Pyrrolidinones</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Rhinovirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine endopeptidases</term>
<term>Inhibiteurs de protéases</term>
<term>Protéines virales</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de protéases</term>
<term>Isoxazoles</term>
<term>Pyrrolidones</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term>
<term>Humans</term>
<term>Protein Structure, Tertiary</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Inhibiteurs de protéases</term>
<term>Isoxazoles</term>
<term>Pyrrolidones</term>
<term>Rhinovirus</term>
<term>Sites de fixation</term>
<term>Structure tertiaire des protéines</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Tianjin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Guo, Yu" sort="Guo, Yu" uniqKey="Guo Y" first="Yu" last="Guo">Yu Guo</name>
<name sortKey="Lou, Zhiyong" sort="Lou, Zhiyong" uniqKey="Lou Z" first="Zhiyong" last="Lou">Zhiyong Lou</name>
<name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name>
<name sortKey="Yan, Liming" sort="Yan, Liming" uniqKey="Yan L" first="Liming" last="Yan">Liming Yan</name>
<name sortKey="Yang, Cheng" sort="Yang, Cheng" uniqKey="Yang C" first="Cheng" last="Yang">Cheng Yang</name>
<name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Ren, Zhilin" sort="Ren, Zhilin" uniqKey="Ren Z" first="Zhilin" last="Ren">Zhilin Ren</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001834 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001834 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:23549610
   |texte=   The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23549610" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.

Source :

Descripteurs français

English descriptors

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.